publication bias

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Big Pharma Plays Hide-The-Ball With Data

Ben Wolford | Newsweek | November 13, 2014

...[E]vidence released earlier this year by  Cochrane Collaboration, a London-based nonprofit, shows that a significant amount of negative data from [Tamiflu's] clinical trials were hidden from the public. The Food and Drug Administration (FDA) knew about it, but the medical community did not; the U.S. Centers for Disease Control and Prevention (CDC), which doesn’t have the same access to unpublished data as regulators, had recommended the drug without being able to see the full picture...

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Many Antidepressant Studies Found Tainted by Pharma Company Influence

Roni Jacobson | Scientific American | October 21, 2015

The latest study, published in the Journal of Clinical Epidemiology, which evaluated 185 meta-analyses, found that one third of them were written by pharma industry employees. “We knew that the industry would fund studies to promote its products, but it’s very different to fund meta-analyses,” which “have traditionally been a bulwark of evidence-based medicine,” says John Ioannidis, an epidemiologist at Stanford University School of Medicine and co-author of the study. “It’s really amazing that there is such a massive influx of influence in this field.”

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Policy: NIH Plans to Enhance Reproducibility of Biomedical Research

In a recent editorial in the journal Nature, Francis Collins and Lawrence Tabak from the National Institutes of Health (NIH) discuss the concerns that NIH has with current lack of reproducibility in biomedical research, and propose steps for improving the repoducibility records. In their editorial they point out that we have traditionally considered science to be a self-correcting field. Given the expectation that over time, all reported works would be replicated by peers. Read More »